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Antimicrob Agents Chemother. 1978 March; 13(3): 527-532

Mode of action of the Haemophilus bactericidal factor.

R G Streker, R A Venezia and R G Robertson

ABSTRACT

Haemocin, a bacteriocin produced by Haemophilus influenzae b, caused pronounced cell elongation of the sensitive strains H. influenzae Rd and Escherichia coli CR34 thyA. In the sensitive strains, haemocin markedly inhibited the synthesis of deoxyribonucleic acid (DNA) but did not affect either ribonucleic acid or protein synthesis. The observed inhibition in synthesis of DNA was not due to degradation of preexisting DNA. The data suggest that haemocin may specifically inhibit DNA synthesis.

Antimicrob Agents Chemother. 1978 March; 13(3): 527-532




This article has been cited by other articles:

  • Terry, T. D., Zalucki, Y. M., Walsh, S. L., Blackall, P. J., Jennings, M. P. (2003). Genetic analysis of a plasmid encoding haemocin production in Haemophilus paragallinarum. Microbiology 149: 3177-3184 [Abstract] [Full Text]  


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