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Antimicrob Agents Chemother. 1978 November; 14(5): 723-726
Copyright © 1978 American Society for Microbiology. All Rights Reserved.

Penetration of Methicillin, Oxacillin, and Cephalothin into Bone and Synovial Tissues

Robert H. Fitzgerald Jr., Patrick J. Kelly, Robert J. Snyder and John A. Washington II

1 Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

ABSTRACT

The penetrations of methicillin, oxacillin, and cephalothin into cortical bone and synovial tissues were studied 1 h after their intravenous administration in 105 patients having arthroplasty of the hip. Although the lowest serum levels were noted with cephalothin (P < 0.01), more patients receiving cephalothin achieved osseous drug levels inhibitory to staphylococci (P < 0.01). Differences in the penetration of the three agents into synovial tissues were not statistically significant.

Antimicrob Agents Chemother. 1978 November; 14(5): 723-726
Copyright © 1978 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Darley, E. S. R., MacGowan, A. P. (2004). Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemother 53: 928-935 [Abstract] [Full Text]  


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