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Antimicrob Agents Chemother. 1978 December; 14(6): 919-921
Copyright © 1978 American Society for Microbiology. All Rights Reserved.

Comparative Evaluation of Piperacillin in Vitro

Gordon M. Dickinson1, Timothy J. Cleary1 and Thomas A. Hoffman2

2 Department of Medicine, Division of Infectious Diseases, University of Miami School of Medicine, Miami, Florida 33152
1 Department of Pathology, University of Miami School of Medicine, Miami, Florida 33152

ABSTRACT

The minimal inhibitory concentrations of piperacillin and seven other betalactam antibiotics were determined against 407 bacterial isolates. Piperacillin was found to be more active than ampicillin against susceptible gram-negative bacilli and more active than either carbenicillin or ticarcillin against Pseudomonas aeruginosa and streptococci. Although piperacillin was active against Klebsiella pneumoniae, this activity was less than that of the cephalosporins. Piperacillin was not active against penicillin-resistant Staphylococcus aureus and Enterobacteriaceae that were resistant to the other test antibiotics.

Antimicrob Agents Chemother. 1978 December; 14(6): 919-921
Copyright © 1978 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • ELIOPOULOS, G. M., MOELLERING, R. C. Jr. (1982). Azlocillin, Mezlocillin, and Piperacillin: New Broad-Spectrum Penicillins. ANN INTERN MED 97: 755-760 [Abstract]  
  • Marier, R. L., Sanders, C. V., Faro, S., Janney, A., Williams, W. W., Derks, F., Aldridge, K. E. (1982). Piperacillin v Carbenicillin in the Therapy for Serious Infections. Arch Intern Med 142: 2000-2005 [Abstract]  
  • Kaye, D. (1982). Enterococci: Biologic and Epidemiologic Characteristics and In Vitro Susceptibility. Arch Intern Med 142: 2006-2009 [Abstract]  


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