This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pappagianis, D.
Right arrow Articles by Remington, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pappagianis, D.
Right arrow Articles by Remington, J.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1979 August; 16(2): 123-126
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human

D. Pappagianis1, M. S. Collins1, R. Hector1 and J. Remington2

1 Department of Medical Microbiology, University of California, Davis, California 95616,
2 Section of Infectious Diseases, Stanford School of Medicine, Stanford, California 94305

ABSTRACT

Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 µg of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 µg/ml, respectively, for complete inhibition at 48 h.

Antimicrob Agents Chemother. 1979 August; 16(2): 123-126
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Diekema, D. J., Messer, S. A., Boyken, L. B., Hollis, R. J., Kroeger, J., Tendolkar, S., Pfaller, M. A. (2009). In Vitro Activity of Seven Systemically Active Antifungal Agents against a Large Global Collection of Rare Candida Species as Determined by CLSI Broth Microdilution Methods. J. Clin. Microbiol. 47: 3170-3177 [Abstract] [Full Text]  
  • Rossignol, T., Lechat, P., Cuomo, C., Zeng, Q., Moszer, I., d'Enfert, C. (2008). CandidaDB: a multi-genome database for Candida species and related Saccharomycotina. Nucleic Acids Res 36: D557-D561 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J. (2004). Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyond Candida albicans and Aspergillus fumigatus. J. Clin. Microbiol. 42: 4419-4431 [Full Text]  
  • Canton, E., Peman, J., Gobernado, M., Viudes, A., Espinel-Ingroff, A. (2004). Patterns of Amphotericin B Killing Kinetics against Seven Candida Species. Antimicrob. Agents Chemother. 48: 2477-2482 [Abstract] [Full Text]  
  • Young, L. Y., Hull, C. M., Heitman, J. (2003). Disruption of Ergosterol Biosynthesis Confers Resistance to Amphotericin B in Candida lusitaniae. Antimicrob. Agents Chemother. 47: 2717-2724 [Abstract] [Full Text]  
  • Noel, T., Francois, F., Paumard, P., Chastin, C., Brethes, D., Villard, J. (2003). Flucytosine-Fluconazole Cross-Resistance in Purine-Cytosine Permease-Deficient Candida lusitaniae Clinical Isolates: Indirect Evidence of a Fluconazole Uptake Transporter. Antimicrob. Agents Chemother. 47: 1275-1284 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J., Messer, S. A., Boyken, L., Hollis, R. J., Jones, R. N. (2003). In Vitro Activities of Voriconazole, Posaconazole, and Four Licensed Systemic Antifungal Agents against Candida Species Infrequently Isolated from Blood. J. Clin. Microbiol. 41: 78-83 [Abstract] [Full Text]  
  • McClenny, N. B., Fei, H., Baron, E. J., Gales, A. C., Houston, A., Hollis, R. J., Pfaller, M. A. (2002). Change in Colony Morphology of Candida lusitaniae in Association with Development of Amphotericin B Resistance. Antimicrob. Agents Chemother. 46: 1325-1328 [Abstract] [Full Text]  
  • Francois, F., Noel, T., Pepin, R., Brulfert, A., Chastin, C., Favel, A., Villard, J. (2001). Alternative Identification Test Relying upon Sexual Reproductive Abilities of Candidalusitaniae Strains Isolated from Hospitalized Patients. J. Clin. Microbiol. 39: 3906-3914 [Abstract] [Full Text]  
  • Arthington-Skaggs, B. A., Motley, M., Warnock, D. W., Morrison, C. J. (2000). Comparative Evaluation of PASCO and National Committee for Clinical Laboratory Standards M27-A Broth Microdilution Methods for Antifungal Drug Susceptibility Testing of Yeasts. J. Clin. Microbiol. 38: 2254-2260 [Abstract] [Full Text]  
  • Young, L. Y., Lorenz, M. C., Heitman, J. (2000). A STE12 Homolog Is Required for Mating but Dispensable for Filamentation in Candida lusitaniae. Genetics 155: 17-29 [Abstract] [Full Text]  
  • Clancy, C. J., Nguyen, M. H. (1999). Correlation between In Vitro Susceptibility Determined by E Test and Response to Therapy with Amphotericin B: Results from a Multicenter Prospective Study of Candidemia. Antimicrob. Agents Chemother. 43: 1289-1290 [Abstract] [Full Text]  
  • Yoon, S. A., Vazquez, J. A., Steffan, P. E., Sobel, J. D., Akins, R. A. (1999). High-Frequency, In Vitro Reversible Switching of Candida lusitaniae Clinical Isolates from Amphotericin B Susceptibility to Resistance. Antimicrob. Agents Chemother. 43: 836-845 [Abstract] [Full Text]  
  • Verweij, P. E., Oakley, K. L., Morrissey, J., Morrissey, G., Denning, D. W. (1998). Efficacy of LY303366 against Amphotericin B-Susceptible and -Resistant Aspergillus fumigatus in a Murine Model of Invasive Aspergillosis. Antimicrob. Agents Chemother. 42: 873-878 [Abstract] [Full Text]  
  • White, T. C., Marr, K. A., Bowden, R. A. (1998). Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance. Clin. Microbiol. Rev. 11: 382-402 [Abstract] [Full Text]  
  • Davey, K. G., Holmes, A. D., Johnson, E. M., Szekely, A., Warnock, D. W. (1998). Comparative Evaluation of FUNGITEST and Broth Microdilution Methods for Antifungal Drug Susceptibility Testing of Candida Species and Cryptococcus neoformans. J. Clin. Microbiol. 36: 926-930 [Abstract] [Full Text]  
  • Yuen, J. R., Jaresko, G. S. (1991). Pharmacotherapeutics of Ocular Infections. Journal of Pharmacy Practice 4: 247-268  
  • DICK, J. D., ROSENGARD, B. R., MERZ, W. G., STUART, R. K., HUTCHINS, G. M., SARAL, R. (1985). Fatal Disseminated Candidiasis Due to Amphotericin-B-Resistant Candida guilliermondii. ANN INTERN MED 102: 67-68 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»