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Antimicrob Agents Chemother. 1979 August; 16(2): 150-157
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Comparative Activity and ß-Lactamase Stability of Cefoperazone, a Piperazine Cephalosporin

Harold C. Neu, Kwung P. Fu, Nalinee Aswapokee, Prasit Aswapokee and Ket Kung

1 Division of Infectious Diseases, Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

The in vitro activity and ß-lactamase stability of 7-[D(–)-{alpha}-(4-ethyl-2,3-dioxopiperazino-carbonylamino) -p-hydroxyphenylacetamido]-3-[(1-methyl)-5-tetrazolylthiomethyl] -{Delta}3-cephem-4-carboxylic acid (cefoperazone), a cephalosporin analog of piperacillin, were compared with the activities and stabilities of other cephalosporins and cephamycins. The compound was less active than cephalothin or cefamandole in inhibiting Staphylococcus aureus; it was as active as cefamandole and cefoxitin against most of the Enterobacteriaceae but less active than cefotaxime. It was more active than carbenicillin or piperacillin against Pseudomonas aeruginosa. In general, the compound was not active against Bacteroides. It was hydrolyzed by the ß-lactamases of some Escherichia coli which hydrolyzed cefamandole, but was stable to most plasmid-mediated, chromosomally mediated, inducible ß-lactamases in the Enterobacteriaceae and Pseudomonas.

Antimicrob Agents Chemother. 1979 August; 16(2): 150-157
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Axelrod, J. L., Kochman, R. S., Horowitz, M. A., Youngworth, L. (1984). Ceftazidime Concentrations in Human Aqueous Humor. Arch Ophthalmol 102: 923-925 [Abstract]  
  • NEU, H. C. (1982). The New Beta-Lactamase-Stable Cephalosporins. ANN INTERN MED 97: 408-419 [Abstract]  


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