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Antimicrob Agents Chemother. 1979 August; 16(2): 225-230
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Persistence of Plasmid-Carrying Tetracycline-Resistant Escherichia coli in a Married Couple, One of Whom Was Receiving Antibiotics

V. Petrocheilou, M. H. Richmond and P. M. Bennett

1 Department of Bacteriology, University of Bristol, Bristol BS8 1TD, England

ABSTRACT

This paper describes an extension to an earlier account of the coliform flora carried by a married couple, one of whom was taking tetracycline for prolonged periods. The latter phase of this study was notable for the following: first, certain tetracycline-resistant Escherichia coli O antigen types persisted in one of the participants for several weeks after tetracycline was withdrawn; second, a course of ampicillin led to replacement of the tetracycline-resistant flora by one that was ampicillin resistant, but the end of the ampicillin course led to the reappearance of the tetracycline-resistant line, even though no tetracycline was being taken; and third, the tetracycline-sensitive O75 E. coli, which appeared toward the end of the survey, had not lost their plasmid but carried a derivative in which the tetracycline resistance gene(s) had been inactivated by the insertion of an extra piece of deoxyribonucleic acid with a molecular weight of about 1 megadalton.

Antimicrob Agents Chemother. 1979 August; 16(2): 225-230
Copyright © 1979, American Society for Microbiology. All Rights Reserved.





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