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Antimicrob Agents Chemother. 1979 August; 16(2): 234-236
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of E-5-(2-Bromovinyl)-2'-Deoxyuridine in Mice

E. de Clercq1, J. Descamps1, P. de Somer1, P. J. Barr2, A. S. Jones2 and R. T. Walker2

1 Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
2 Department of Chemistry, University of Birmingham, Birmingham B15 2TT, Great Britain

ABSTRACT

The pharmacokinetics of the newly developed anti-herpes agent, E-5-(2-bromovinyl)-2'-deoxyuridine, was compared with that of the standard anti-herpes drug 5-iodo-2'-deoxyuridine. Both compounds were administered to mice at 100 mg/kg by either the intraperitoneal, subcutaneous, or oral route. The active blood drug levels achieved by E-5-(2-bromovinyl)-2'-deoxyuridine were considerably higher than those attained by 5-iodo-2'-deoxyuridine (serum peak concentrations: 40 to 100 and 4 to 10 µg/ml, respectively). Active blood drug levels could still be found 320 min after oral administration of E-5-(2-bromovinyl)-2'-deoxyuridine.

Antimicrob Agents Chemother. 1979 August; 16(2): 234-236
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Maudgal, P. C., Uyttebroeck, W., De Clercq, E., Missotten, L. (1982). Oral and Topical Treatment of Experimental Herpes Simplex Iritis With Bromovinyldeoxyuridine. Arch Ophthalmol 100: 1337-1340 [Abstract]  


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