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Antimicrob Agents Chemother. 1979 August; 16(2): 240-242
Copyright © 1979, American Society for Microbiology. All Rights Reserved.

Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Kuni Takayama1, Emma L. Armstrong1, Keith A. Kunugi1 and James O. Kilburn2

1 Tuberculosis Research Laboratory, William S. Middleton Memorial Veterans Medical Center, Madison, Wisconsin 53705; Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin 53706;
2 Bureau of Laboratories, Center for Disease Control, Atlanta, Georgia 30333

ABSTRACT

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

Antimicrob Agents Chemother. 1979 August; 16(2): 240-242
Copyright © 1979, American Society for Microbiology. All Rights Reserved.



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