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Antimicrob Agents Chemother. 1979 September; 16(3): 283-286

Activity of semisynthetic penicillins and synergism with mecillinam against Bacteroides species.

I Trestman, D Kaye and M E Levison

ABSTRACT

The minimal inhibitory concentrations (MIC) of six penicillins (ampicillin, carbenicillin, ticarcillin, piperacillin, mezlocillin, and Bay k 4999) against 29 clinical isolates of Bacteriodes spp. (including Bacteroides fragilis, Bacteroides thetaiotaomicron, and Bacteroides vulgatus) were determined by an agar dilution method. Bay k 4999 was most active, followed in descending order by ampicillin, piperacillin, mezlocillin, ticarcillin, and carbenicillin. Mecillinam, a 6 beta-amidino-penicillanic acid, inhibited no strains at 50 micrograms/ml, but when compared with ampicillin, a fourfold or greater increase in MIC for ampicillin (antagonism) was noted in 3 of 29 strains, with no effect on MIC for 26 strains, whereas when combined with carbenicillin, a fourfold or greater decrease in MIC for both antibiotics (synergism) was noted in 12 strains, 4 of which had an MIC of greater than or equal to 250 micrograms/ml for carbenicillin alone. These studies demonstrate the increased activity of some newer semisynthetic penicillins and the potential synergy obtained with mecillinam and carbenicillin against Bacteroides sp.

Antimicrob Agents Chemother. 1979 September; 16(3): 283-286




This article has been cited by other articles:

  • ELIOPOULOS, G. M., MOELLERING, R. C. Jr. (1982). Azlocillin, Mezlocillin, and Piperacillin: New Broad-Spectrum Penicillins. ANN INTERN MED 97: 755-760 [Abstract]  


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