This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Klastersky, J Articles by Mombelli, G Search for Related Content PubMed PubMed Citation Articles by Klastersky, J Articles by Mombelli, G

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1979 September; 16(3): 366-371

Anaerobic infection in cancer patients: comparative evaluation of clindamycin and cefoxitin.

J Klastersky, L Coppens and G Mombelli

ABSTRACT

Clindamycin and cefoxitin with or without gentamicin were administered to cancer patients having localized infections presumably caused by anaerobic pathogens. The rates of favorable response were 89% in patients receiving clindamycine alone and 78% in patients receiving cefoxitin alone. When the total experience is considered (clindamycin or cefoxitin with and without gentamicin), 20 of 24 patients (83%) responded to clindamycin and 18 of 22 (82%) responded to cefoxitin. Both therapies were well tolerated. Clindamycin was found to be more effective than cefoxitin in eradicating the offending anaerobic pathogens from the site of infection. Aerobic pathogens were frequently isolated along with anaerobes from the infectious sites in this series; their susceptibility or resistance to clindamycin or cefoxitin did not influence the therapeutic response.

---

Antimicrob Agents Chemother. 1979 September; 16(3): 366-371

This article has been cited by other articles:

• Nicolle, L. E., Harding, G. K. M., Louie, T. J., Thomson, M. J., Blanchard, R. J. (1986). Cefoxitin Plus Tobramycin and Clindamycin Plus Tobramycin: A Prospective Randomized Comparison in the Therapy of Mixed Aerobic/Anaerobic Infections. Arch Surg 121: 891-896 [Abstract]  
• Bartlett, J. G., Dezfulian, M., Joiner, K. (1983). Relative Efficacy and Critical Interval of Antimicrobial Agents in Experimental Infections Involving Bacteroides fragilis. Arch Surg 118: 181-184 [Abstract]