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Antimicrob Agents Chemother. 1979 September; 16(3): 372-377

High-pressure liquid chromatography analysis of antibiotic susceptibility disks.

R B Hagel, E H Waysek and W M Cort

ABSTRACT

The analysis of antibiotic susceptibility disks by high-pressure liquid chromatography (HPLC) was investigated. Methods are presented for the potency determination of mecillinam, ampicillin, carbenicillin, and cephalothin alone and in various combinations. Good agreement between HPLC and microbiological data is observed for potency determinations with recoveries of greater than 95%. Relative standard deviations of lower than 2% are recorded for each HPLC method. HPLC methods offer improved accuracy and greater precision when compared to the standard microbiological methods of analysis for susceptibility disks.

Antimicrob Agents Chemother. 1979 September; 16(3): 372-377






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