This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sud, I J Articles by Feingold, D S Search for Related Content PubMed PubMed Citation Articles by Sud, I J Articles by Feingold, D S

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1979 October; 16(4): 486-490

Lipid composition and sensitivity of Prototheca wickerhamii to membrane-active antimicrobial agents.

I J Sud and D S Feingold

ABSTRACT

The lipid composition of Prototheca wickerhamii ATCC 16529 is presented and discussed in relation to the unique susceptibility of the organism to drugs of three membrane-active antimicrobial classes: the polyenes, the polymyxins, and the imidazoles. The presence of ergosterol in the neutral lipid fraction of the membrane is likely responsible for the exquisite susceptibility to amphotericin B. The presence of a large quantity of free fatty acids in the membrane appears responsible for imidazole susceptibility. The membrane determinants of polymyxin B susceptibility are less well defined.

---

Antimicrob Agents Chemother. 1979 October; 16(4): 486-490

This article has been cited by other articles:

• Lass-Florl, C., Mayr, A. (2007). Human Protothecosis. Clin. Microbiol. Rev. 20: 230-242 [Abstract] [Full Text]  
• Pegram, P. S. Jr, Kerns, F. T., Wasilauskas, B. L., Hampton, K. D., Scharyj, M., Burke, J. G. (1983). Successful Ketoconazole Treatment of Protothecosis With Ketoconazole-Associated Hepatotoxicity. Arch Intern Med 143: 1802-1805 [Abstract]