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Antimicrob Agents Chemother. 1979 November; 16(5): 589-591

Biosynthetic pathway leading to gentamicin C2b.

B K Lee, T L Nagabhushan, R G Condon, G Shimonaski, M G Kalyanpur, M Patel and J A Waitz

ABSTRACT

Incubation of Micromonospora purpurea SC 1210 (NRRL 5467) with L-[methyl-14C]methionine yielded [methyl-14C]gentamicin A and methyl-14C-labeled antibiotic JI-20A in a molar radioactivity ratio of 9:2. We did not isolate methyl-14C-labeled gentamicin X2, which was expected as an intermediate based on the biosynthetic pathways proposed by others. Addition of methyl-14C-labeled antibiotic JI-20A to M. purpurea SC 1124 (NRRL 8102) yielded [methyl-14C]-gentamicin C1a and [methyl-14C]gentamicin C2b in variable molar radioactivity ratios. These data do not support the biosynthetic pathway leading to gentamicin C2b proposed by Testa and Tilley.

Antimicrob Agents Chemother. 1979 November; 16(5): 589-591






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