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Antimicrob Agents Chemother. 1980 October; 18(4): 502-505

Tetracycline transport in Bacteroides fragilis.

F Fayolle, G Privitera and M Sebald

ABSTRACT

In susceptible strain of Bacteroides fragilis, tetracycline uptake is biphasic. The initial phase is independent of adenosine 5'-triphosphate synthesis, which is coupled to fumarate reduction; this phase is not altered by expression of tetracycline resistance genes in a resistant strain. The second phase appears to occur by active transport, since it is largely reduced by rotenone, an inhibitor of electron transport to fumarate; moreover, this phase is under negative control of the tetracycline resistance gene.

Antimicrob Agents Chemother. 1980 October; 18(4): 502-505






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