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Antimicrob Agents Chemother. 1980 October; 18(4): 642-644

In vitro activity of N-formimidoyl thienamycin (MK0787).

F P Tally, N V Jacobus and S L Gorbach

ABSTRACT

The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.

Antimicrob Agents Chemother. 1980 October; 18(4): 642-644






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