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Antimicrob Agents Chemother. 1981 February; 19(2): 349-351

Mode of action of Myxococcus xanthus antibiotic TA.

D Zafriri, E Rosenberg and D Mirelman

ABSTRACT

Antibiotic TA inhibited incorporation of diaminopimelic acid and uridine diphosphate-N-acetylglucosamine into Escherichia coli cell walls without altering the ratio of cross-linked to uncross-linked peptidoglycan. Formation of the lipid intermediate was not blocked by TA, suggesting that TA interferes with polymerization of the lipid-disaccharide-pentapeptide.

Antimicrob Agents Chemother. 1981 February; 19(2): 349-351




This article has been cited by other articles:

  • Paitan, Y., Orr, E., Ron, E. Z., Rosenberg, E. (1999). Genetic and functional analysis of genes required for the post-modification of the polyketide antibiotic TA of Myxococcus xanthus. Microbiology 145: 3059-3067 [Abstract] [Full Text]  
  • Paitan, Y., Orr, E., Ron, E. Z., Rosenberg, E. (1999). A Nonessential Signal Peptidase II (Lsp) of Myxococcus xanthus Might Be Involved in Biosynthesis of the Polyketide Antibiotic TA. J. Bacteriol. 181: 5644-5651 [Abstract] [Full Text]  
  • Kimura, Y., Takashima, Y., Tokumasu, Y., Sato, M. (1999). Molecular Cloning, Sequence Analysis, and Characterization of a Penicillin-Resistant DD-Carboxypeptidase of Myxococcus xanthus. J. Bacteriol. 181: 4696-4699 [Abstract] [Full Text]  
  • Manor, A., Varon, M., Rosenberg, E. (1985). Adsorption of Antibiotic TA to Dental Hard Tissues. JDR 64: 1371-1373  


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