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Antimicrob Agents Chemother. 1972 September; 2(3): 224-228
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Isoprinosine Against Influenza and Some Other Viruses Causing Respiratory Diseases

Robert L. Muldoon, Linda Mezny and George G. Jackson

Virology Department, Hektoen Research Institute of Cook County Hospital, and Department of Medicine, University of Illinois Hospital, Abraham Lincoln School of Medicine, University of Illinois, Chicago, Illinois 60680

ABSTRACT

The antiviral activity of isoprinosine was tested in tissue cultures and mice. In tissue cultures, concentrations of 25 to 100 µg/ml inhibited the infectivity of influenza and herpes hominis viruses but not parainfluenza virus, rhinovirus, or adenovirus. Among different strains of influenza A, there was considerable variability in the inhibitory concentration of isoprinosine. For influenza B, a zone effect was observed in the inhibitory drug concentration. Oral prophylactic administration of isoprinosine beginning 24 hr before infection with an intermediate challenge dose of influenza A and continued as treatment for 5 days produced a significant reduction in mortality. No protection was provided against a high dose challenge. Oral or intraperitoneal treatment of mice beginning 24 hr after infection with influenza A or B viruses significantly delayed or prevented death when the drug was administered for 10 days, but not when treatment was limited to 4 days. An increased fatality rate which occurred in treated mice given a virus dose of low lethality could not be attributed to drug toxicity.

Antimicrob Agents Chemother. 1972 September; 2(3): 224-228
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kalimo, K. O. K., Joronen, I. A., Havu, V. K. (1983). Failure of Oral Inosiplex Treatment of Recurrent Herpes Simplex Virus Infections. Arch Dermatol 119: 463-467 [Abstract]  


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