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Antimicrob Agents Chemother. 1982 August; 22(2): 342-345

Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.

F D Gillin, D S Reiner and M Suffness

ABSTRACT

Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.

Antimicrob Agents Chemother. 1982 August; 22(2): 342-345






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