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Antimicrob Agents Chemother. 1983 August; 24(2): 279-281

Intraperitoneal penetration of cefotetan.

R Wise, I A Donovan, J Drumm, J Dent and S A Bennett

ABSTRACT

The intraperitoneal penetration of cefotetan was studied after a 1-g intravenous injection in 25 patients undergoing elective gastrointestinal surgery. Levels of peritoneal fluid were high within 10 min after administration and increased to 44% of the serum levels after 30 min, rising to 115% at 3 h. The mean concentration of cefotetan between 3 and 5 h after administration was 32.3 micrograms/ml. These findings suggest that 1 g of cefotetan administered before abdominal surgery would result in intraperitoneal cefotetan levels necessary to inhibit susceptible pathogens for 5 h or more.

Antimicrob Agents Chemother. 1983 August; 24(2): 279-281






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