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Antimicrob Agents Chemother. 1985 May; 27(5): 791-797

Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli.

J F Garcia-Bustos, N Pezzi and E Mendez

ABSTRACT

Microcin 7 is a small peptide produced and excreted to the culture medium by stationary-phase Escherichia coli cells harboring the pMccC7 plasmid (formerly named pRYC7). This peptide inhibited the growth of the enterobacteria phylogenetically closer to E. coli, apparently by blocking protein biosynthesis. The molecule was degraded with trypsin, and the resulting fragments were purified and sequenced. The results show that microcin 7 is a linear heptapeptide blocked at both ends.

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Antimicrob Agents Chemother. 1985 May; 27(5): 791-797

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