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Antimicrob Agents Chemother. 1985 May; 27(5): 798-801

Relationship between butirosin biosynthesis and sporulation in Bacillus circulans.

D H Nam and D D Ryu

ABSTRACT

The relationship between butirosin biosynthesis and certain biochemical characteristics related to sporulation in a strain of Bacillus circulans NRRL B-3313 was examined. The cellular content of dipicolinic acid increased while the amount of poly-beta-hydroxybutyrate decreased with changes in antibiotic productivity. Oligosporogenous mutants failed to synthesize the antibiotic and to degrade poly-beta-hydroxybutyrate. These observations suggest that spore formation may be related to antibiotic production in this strain of B. circulans.

Antimicrob Agents Chemother. 1985 May; 27(5): 798-801






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