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Antimicrob Agents Chemother. 1986 January; 29(1): 161-162

Comparative activities of UK-49,858 and amphotericin B against Blastomyces dermatitidis infections in mice.

C A Lyman, A M Sugar and R D Diamond

ABSTRACT

UK-49,858, a new antifungal triazole derivative, was compared with amphotericin B in the treatment of pulmonary infections by Blastomyces dermatitidis in male BALB/cByJ mice. Administration of UK-49,858 in daily doses of 25 or 50 mg/kg for 21 days gave 30 and 100% survival rates, respectively. These results compared with 100% mortality in infected controls and 100% survival among mice treated with amphotericin B. UK-49,858 did not eradicate the fungus from the lungs of surviving animals, while amphotericin B effected sterilization of the lungs in 66% of the survivors.

Antimicrob Agents Chemother. 1986 January; 29(1): 161-162




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