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Antimicrob Agents Chemother. 1986 February; 29(2): 284-288

New agents active against African swine fever virus.

A Sola, S Rodríguez, C Gil-Fernández, B Alarcón, M E González and L Carrasco

ABSTRACT

Actinobolin, atropine, carrageenan, megalomycin C, suramin, and tetracenomycin C were tested for their activity against African swine fever virus replication. Both viral inhibitory potency and cytotoxicity were investigated. Megalomycin C, suramin, atropine, and carrageenan exhibited significant activity. Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the formation of infectious virus by 50%. Suramin was the next most active agent in this respect, but because of its lower cytotoxicity, it had the most favorable therapeutic index.

Antimicrob Agents Chemother. 1986 February; 29(2): 284-288






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Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 1986 by the American Society for Microbiology. All rights reserved.