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Antimicrob Agents Chemother. 1986 February; 29(2): 346-349

Comparative in vitro antimicrobial activity of carumonam, a new monocyclic beta-lactam.

B R Smith, J L LeFrock, R V McCloskey, J B Donato, S J Weber and W S Joseph

ABSTRACT

The antimicrobial activity of carumonam (formerly RO-17-2301), a monocyclic beta-lactam antibiotic, was compared with those of aztreonam, cefotaxime, cefoperazone, ceftazidime, piperacillin, and gentamicin against 455 bacterial isolates. Carumonam did not possess activity against gram-positive cocci and was generally comparable to aztreonam and ceftazidime for most gram-negative bacilli. However, carumonam was the most active beta-lactam against gentamicin-resistant Pseudomonas aeruginosa strains (90% MIC, 8 micrograms/ml).

Antimicrob Agents Chemother. 1986 February; 29(2): 346-349






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