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Antimicrob Agents Chemother. 1973 February; 3(2): 279-288
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Molecular Characterization of the R Factors Implicated in the Carbenicillin Resistance of a Sequence of Pseudomonas aeruginosa Strains Isolated from Burns

Lewis C. Ingram, M. H. Richmond and R. B. Sykes

1 Department of Bacteriology, University of Bristol, Bristol, BS8 1TH, England

ABSTRACT

An outbreak of R-factor-mediated carbenicillin resistance in Pseudomonas aeruginosa in burned patients in March 1969 was followed by a second outbreak 6 months later. No R-factor-carrying P. aeruginosa strains were detected in the intervening period but R-factor-determined lactamase was commonly encountered, particularly in Klebsiella aerogenes strains. A comparison of the molecular properties of the R factors in pseudomonads from the first and second phases with those in the Klebsiella strains from the intervening period showed them to be very closely related. A single R-factor type therefore may have been maintained in the Burns Unit between the two Pseudomonas outbreaks as a plasmid conferring resistance to ampicillin in K. aerogenes.

Antimicrob Agents Chemother. 1973 February; 3(2): 279-288
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



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