This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wyde, P R Articles by Smith, R H Search for Related Content PubMed PubMed Citation Articles by Wyde, P R Articles by Smith, R H

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1986 December; 30(6): 942-944

Protection of mice from lethal influenza virus infection with high dose-short duration ribavirin aerosol.

P R Wyde, S Z Wilson, B E Gilbert and R H Smith

ABSTRACT

An aerosol generated from a reservoir containing 60 mg of ribavirin per ml given for 2 h twice daily for 4 days afforded the same high level of protection against lethal influenza virus infection of mice as a longer, conventional treatment schedule (20 mg/ml given for 11 h daily for 4 days). Incremental decreases in ribavirin concentration made while maintaining the 2-h intermittent schedule provided progressively less protection of mice. Mice exposed to the 60-mg/ml doses had significantly increased pulmonary and serum drug levels when compared with mice given 20 mg of drug per ml, these increases were transient, and no evidence of pulmonary intolerance was detected. These studies suggest that protective effects of ribavirin against influenza virus infection can be achieved without untoward effects if higher doses and shorter periods of administration are used.

---

Antimicrob Agents Chemother. 1986 December; 30(6): 942-944

This article has been cited by other articles:

• Nichols, W. G., Peck Campbell, A. J., Boeckh, M. (2008). Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances. Clin. Microbiol. Rev. 21: 274-290 [Abstract] [Full Text]  
• Sudo, K., Watanabe, W., Konno, K., Sato, R., Kajiyashiki, T., Shigeta, S., Yokota, T. (1999). Efficacy of RD3-0028 Aerosol Treatment against Respiratory Syncytial Virus Infection in Immunosuppressed Mice. Antimicrob. Agents Chemother. 43: 752-757 [Abstract] [Full Text]