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Antimicrob Agents Chemother. 1987 January; 31(1): 111-113

Activity of purine analogs against Leishmania donovani in vivo.

J D Berman, W L Hanson, J K Lovelace, V B Waits, J E Jackson, W L Chapman Jr and R S Klein

ABSTRACT

The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activities were greater than that of the experimental clinical agent allopurinol and comparable to that of the classical agent parenteral pentavalent antimony, 9-deazainosine should be considered for clinical development for visceral leishmaniasis.

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Antimicrob Agents Chemother. 1987 January; 31(1): 111-113

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