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Antimicrob Agents Chemother. 1987 February; 31(2): 161-163

Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone.

R Wise, B Kirkpatrick, J Ashby and D J Griggs

ABSTRACT

A 400-mg dose of the trifluorinated quinolone Ro 23-6240 was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and cantharidin-induced inflammatory fluid were measured. Absorption was rapid, with a mean peak level in serum of 6.1 micrograms/ml, which was attained 0.71 h after administration. The elimination half-life in serum was 11.95 h. The agent penetrated the inflammatory fluid rapidly; the percent penetration was 89.7%. Urinary recovery of Ro 23-6240 was 58.6% by 72 h.

Antimicrob Agents Chemother. 1987 February; 31(2): 161-163






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