This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Garcia-Bustos, J F Articles by Dougherty, T J Search for Related Content PubMed PubMed Citation Articles by Garcia-Bustos, J F Articles by Dougherty, T J

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1987 February; 31(2): 178-182

Alterations in peptidoglycan of Neisseria gonorrhoeae induced by sub-MICs of beta-lactam antibiotics.

J F Garcia-Bustos and T J Dougherty

ABSTRACT

Exposure of Neisseria gonorrhoeae to sub-MICs of selected beta-lactam antibiotics caused distortion of normal cell morphology. Analysis of the peptidoglycan indicated that the cells were accumulating increased quantities of disaccharide pentapeptide in their cell walls. The O-acetylated form of the disaccharide pentapeptide was not detected among the major peaks. The correlation of antibiotic binding to gonococcal penicillin-binding protein 2 and accumulation of non-O-acetylated disaccharide pentapeptide suggested an explanation for the previously observed relationship of penicillin-binding protein 2 and O-acetylation of peptidoglycan.

---

Antimicrob Agents Chemother. 1987 February; 31(2): 178-182

This article has been cited by other articles:

• Antignac, A., Rousselle, J.-C., Namane, A., Labigne, A., Taha, M.-K., Boneca, I. G. (2003). Detailed Structural Analysis of the Peptidoglycan of the Human Pathogen Neisseria meningitidis. J. Biol. Chem. 278: 31521-31528 [Abstract] [Full Text]  
• Antignac, A., Boneca, I. G., Rousselle, J.-C., Namane, A., Carlier, J.-P., Vazquez, J. A., Fox, A., Alonso, J.-M., Taha, M.-K. (2003). Correlation between Alterations of the Penicillin-binding Protein 2 and Modifications of the Peptidoglycan Structure in Neisseria meningitidis with Reduced Susceptibility to Penicillin G. J. Biol. Chem. 278: 31529-31535 [Abstract] [Full Text]  
• Boneca, I. G., Huang, Z.-H., Gage, D. A., Tomasz, A. (2000). Characterization of Staphylococcus aureus Cell Wall Glycan Strands, Evidence for a New beta -N-Acetylglucosaminidase Activity. J. Biol. Chem. 275: 9910-9918 [Abstract] [Full Text]  
• Boneca, I. G., Xu, N., Gage, D. A., de Jonge, B. L. M., Tomasz, A. (1997). Structural Characterization of an Abnormally Cross-linked Muropeptide Dimer That Is Accumulated in the Peptidoglycan of Methicillin- and Cefotaxime-resistant Mutants of Staphylococcus aureus. J. Biol. Chem. 272: 29053-29059 [Abstract] [Full Text]