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Antimicrob Agents Chemother. 1987 February; 31(2): 183-186

Comparative activity of metronidazole and tinidazole against Clostridium difficile and Peptostreptococcus anaerobius.

A M Jokipii and L Jokipii

ABSTRACT

Broth dilution MICs of metronidazole against 38 strains of Clostridium difficile (0.13 microgram/ml) and 11 strains of Peptostreptococcus anaerobius (0.11 microgram/ml) were lower than those of tinidazole (0.16 and 0.17 microgram/ml, respectively). As molar concentrations the nitroimidazoles were equally active. The MICs of the two drugs correlated positively, and the relative activity of tinidazole increased with decreasing susceptibility of both species.

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Antimicrob Agents Chemother. 1987 February; 31(2): 183-186

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