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Antimicrob Agents Chemother. 1987 February; 31(2): 264-266

Pharmacokinetics of cefoperazone and tobramycin alone and in combination.

B J Guglielmo, J F Flaherty, T M Woods, G LaFollette and J G Gambertoglio

ABSTRACT

Certain beta-lactams have been shown to increase the clearance of tobramycin. We evaluated the pharmacokinetics of cefoperazone and tobramycin, alone and in combination, in healthy volunteers. No significant alteration in pharmacokinetic behavior was noted for cefoperazone or tobramycin alone or in combination.

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Antimicrob Agents Chemother. 1987 February; 31(2): 264-266

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