This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hardy, D J
Right arrow Articles by Fernandes, P B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hardy, D J
Right arrow Articles by Fernandes, P B

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1988 November; 32(11): 1710-1719

Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides.

D J Hardy, D M Hensey, J M Beyer, C Vojtko, E J McDonald and P B Fernandes

Anti-Infective Research Department, Abbott Laboratories, Abbott Park, Illinois 60064.

ABSTRACT

The in vitro activities of several 14-, 15- and 16-membered macrolides were compared with that of erythromycin. In general, 14-membered macrolides such as erythromycin, clarithromycin, and flurithromycin were more active against streptococci and Bordetella pertussis than was the 15-membered macrolide azithromycin, which was more active than 16-membered macrolides such as miocamycin and rokitamycin. Clarithromycin was the most active compound against Streptococcus pyogenes, pneumococci, Listeria monocytogenes, and Corynebacterium species. Legionella pneumophila was most susceptible to miocamycin, clarithromycin, and rokitamycin. Branhamella catarrhalis, Neisseria gonorrhoeae, and Haemophilus influenzae were most susceptible to azithromycin. Azithromycin and dirithromycin were the most active compounds against Campylobacter jejuni. MICs of 16-membered macrolides for strains expressing inducible-type resistance to erythromycin were less than or equal to 1 microgram/ml, whereas none of the compounds had activity against strains expressing constitutive-type resistance. The MICs of roxithromycin, miocamycin, rokitamycin, and josamycin increased in the presence of human serum, whereas MICs of the other compounds either were unchanged or decreased.

Antimicrob Agents Chemother. 1988 November; 32(11): 1710-1719




This article has been cited by other articles:

  • Gibreel, A., Taylor, D. E. (2006). Macrolide resistance in Campylobacter jejuni and Campylobacter coli. J Antimicrob Chemother 58: 243-255 [Abstract] [Full Text]  
  • Dinos, G. P., Connell, S. R., Nierhaus, K. H., Kalpaxis, D. L. (2003). Erythromycin, Roxithromycin, and Clarithromycin: Use of Slow-Binding Kinetics to Compare Their in Vitro Interaction with a Bacterial Ribosomal Complex Active in Peptide Bond Formation. Mol. Pharmacol. 63: 617-623 [Abstract] [Full Text]  
  • Guthrie, R. (2001). Community-Acquired Lower Respiratory Tract Infections : Etiology and Treatment. Chest 120: 2021-2034 [Abstract] [Full Text]  
  • Martin, S. J., Garvin, C. G., McBurney, C. R., Sahloff, E. G. (2001). The activity of 14-hydroxy clarithromycin, alone and in combination with clarithromycin, against penicillin- and erythromycin-resistant Streptococcus pneumoniae. J Antimicrob Chemother 47: 581-587 [Abstract] [Full Text]  
  • Fuchs, P. C., Barry, A. L., Brown, S. D. (2001). Influence of Variations in Test Methods on Susceptibility of Haemophilus influenzae to Ampicillin, Azithromycin, Clarithromycin, and Telithromycin. J. Clin. Microbiol. 39: 43-46 [Abstract] [Full Text]  
  • Wasilewski, M. M., Wilson, M. G., Sides, G. D., Stotka, J. L. (2000). Comparative efficacy of 5 days of dirithromycin and 7 days of erythromycin in skin and soft tissue infections. J Antimicrob Chemother 46: 255-262 [Abstract] [Full Text]  
  • Tsitsika, A., Pefanis, A., Perdikaris, G. S., Donta, I., Karayiannakos, P., Giamarellou, H. (2000). Single-Oral-Dose Azithromycin Prophylaxis against Experimental Streptococcal or Staphylococcal Aortic Valve Endocarditis. Antimicrob. Agents Chemother. 44: 1754-1756 [Abstract] [Full Text]  
  • Jung, R., Messick, C. R., Pendland, S. L., Tesoro, E. P., Losendahl, K. J., Schriever, C. A., Danziger, L. H. (2000). Postantibiotic Effects and Bactericidal Activities of Clarithromycin-14-Hydroxy-Clarithromycin, versus Those of Amoxicillin-Clavulanate, against Anaerobes. Antimicrob. Agents Chemother. 44: 778-779 [Abstract] [Full Text]  
  • Weightman, N. C., Barnham, M. (2000). Effect of the incubation atmosphere on the susceptibilities of Haemophilus influenzae isolates to macrolides and amoxycillin as determined by the Etest. J Antimicrob Chemother 45: 405-406 [Full Text]  
  • Mättö, J., Asikainen, S., Väisänen, M.-L., Von Troil-Lindén, B., Könönen, E., Saarela, M., Salminen, K., Finegold, S. M., Jousimies-Somer, H. (1999). beta -Lactamase Production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens Genotypes and In Vitro Susceptibilities to Selected Antimicrobial Agents. Antimicrob. Agents Chemother. 43: 2383-2388 [Abstract] [Full Text]  
  • Amsden, G. W. (1999). Pneumococcal macrolide resistance—myth or reality?. J Antimicrob Chemother 44: 1-6 [Full Text]  
  • Fish, D. N., Abraham, E. (1999). Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients. Antimicrob. Agents Chemother. 43: 1277-1280 [Abstract] [Full Text]  
  • Bergman, K. L., Olsen, K. M., Peddicord, T. E., Fey, P. D., Rupp, M. E. (1999). Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 43: 1291-1293 [Abstract] [Full Text]  
  • Berry, V., Thorburn, C. E., Knott, S. J., Woodnutt, G. (1998). Bacteriological Efficacies of Three Macrolides Compared with Those of Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. Antimicrob. Agents Chemother. 42: 3193-3199 [Abstract] [Full Text]  
  • Hoppe, J. E., Bryskier, A. (1998). In Vitro Susceptibilities of Bordetella pertussis and Bordetella parapertussis to Two Ketolides (HMR 3004 and HMR 3647), Four Macrolides (Azithromycin, Clarithromycin, Erythromycin A, and Roxithromycin), and Two Ansamycins (Rifampin and Rifapentine). Antimicrob. Agents Chemother. 42: 965-966 [Abstract] [Full Text]  
  • Calhoun, K. H., Hokanson, J. A. (1993). Multicenter Comparison of Clarithromycin and Amoxicillin in the Treatment of Acute Maxillary Sinusitis. Arch Fam Med 2: 837-840 [Abstract]  
  • Weber, J., Leung, J., Swanson, S., Idler, K., McAlpine, J. (1991). An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. Science 252: 114-117 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»