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Antimicrob Agents Chemother. 1989 December; 33(12): 2157-2159

Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391.

E Inoue and S Mitsuhashi

Episome Institute, Gunma, Japan.

ABSTRACT

The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.

Antimicrob Agents Chemother. 1989 December; 33(12): 2157-2159






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