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Antimicrob Agents Chemother. 1989 June; 33(6): 965-967

In vitro activity of SK&F 104662, a new glycopeptide antibiotic.

J D Yao, G M Eliopoulos and R C Moellering Jr

Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts.

ABSTRACT

The in vitro activity of SK&F 104662, a new glycopeptide antibiotic, against gram-positive bacteria was evaluated. Activity was comparable to those of teicoplanin and vancomycin against most organisms. SK&F 104662 inhibited diphtheroids at concentrations of less than or equal to 0.5 microgram/ml. Addition of human serum to the test medium lowered the inhibitory activity of this glycopeptide against some organisms by as much as eightfold.

Antimicrob Agents Chemother. 1989 June; 33(6): 965-967






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