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Antimicrob Agents Chemother. 1990 November; 34(11): 2075-2080

Antimicrobial resistance among respiratory isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in the United States.

J H Jorgensen, G V Doern, L A Maher, A W Howell and J S Redding

Department of Pathology, University of Texas Health Science Center, San Antonio 78284.

ABSTRACT

A national surveillance study was conducted to determine trends in antimicrobial resistance patterns among three common causes of community-acquired respiratory tract infections. Fifteen participating U.S. medical centers submitted clinically significant isolates of Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, and Streptococcus pneumoniae to two central laboratories for testing with a group of 12 antimicrobial agents. The majority of isolates were recovered from adult males greater than 50 years old. Overall, 84.1% of 378 M. catarrhalis and 16.5% of 564 H. influenzae (29.5% of type b strains; 15.0% of non-type b strains) produced beta-lactamase and were thus resistant to penicillin, ampicillin, and amoxicillin. Resistance in H. influenzae to other agents was 2.1% to tetracycline, 0.7% to trimethoprim-sulfamethoxazole, 1.1% to cefaclor, and 0.2% to cefuroxime and amoxicillin-clavulanate, while the M. catarrhalis isolates yielded very low MICs of these latter drugs. As demonstrated in prior studies, erythromycin showed little activity against H. influenzae. Of 487 S. pneumoniae isolates, 1 (0.2%) was penicillin resistant, while 3.8% were relatively resistant to penicillin, 4.5% were resistant to trimethoprim-sulfamethoxazole, 2.3% were resistant to tetracycline, 1.2% were resistant to chloramphenicol, and 0.2% were resistant to erythromycin. Overall, the lowest resistance rates for these common bacterial respiratory pathogens were noted with amoxicillin-clavulanate, cefuroxime, and cefaclor.

Antimicrob Agents Chemother. 1990 November; 34(11): 2075-2080




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  • Pomilla, P. V., Brown, R. B. (1994). Outpatient Treatment of Community-Acquired Pneumonia in Adults. Arch Intern Med 154: 1793-1802 [Abstract]  
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  • Caputo, G. M., Appelbaum, P. C., Liu, H. H. (1993). Infections due to Penicillin-Resistant Pneumococci: Clinical, Epidemiologic, and Microbiologic Features. Arch Intern Med 153: 1301-1310 [Abstract]  
  • Neu, H. C. (1992). The Crisis in Antibiotic Resistance. Science 257: 1064-1073 [Abstract]  


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