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Antimicrob Agents Chemother. 1990 March; 34(3): 473-475

Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.

I Fourel, O Hantz, K A Watanabe, C Jacquet, B Chomel, J J Fox and C Trepo

Unité de Recherche sur les Hépatites, le SIDA et les Rétrovirus Humains, Institut National de la Santé et de la Recherche Médicale U 271, Lyon, France.

ABSTRACT

The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.

Antimicrob Agents Chemother. 1990 March; 34(3): 473-475




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