This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fuchs, P C Articles by Gerlach, E H Search for Related Content PubMed PubMed Citation Articles by Fuchs, P C Articles by Gerlach, E H

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1991 April; 35(4): 764-766

Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates.

St. Vincent Hospital and Medical Center, Portland, Oregon 97225.

ABSTRACT

The in vitro activities of three new quinolones (sparfloxacin, CI-960, and PD 131,628) were compared with that of ciprofloxacin against 5,252 routine clinical aerobic and facultatively anaerobic bacterial isolates. Overall, CI-960 was the most active drug in vitro (MIC for 90% of the strains tested, 0.13 micrograms/ml); ciprofloxacin and sparfloxacin were the least active (MIC for 90% of the strains tested, 1.0 micrograms/ml). All three new quinolones, but particularly CI-960 and PD 131,628, exhibited significantly greater activity than ciprofloxacin against enterococci and staphylococci.

This article has been cited by other articles:

• Wright, D. H., Brown, G. H., Peterson, M. L., Rotschafer, J. C. (2000). Application of fluoroquinolone pharmacodynamics. J Antimicrob Chemother 46: 669-683 [Abstract] [Full Text]  
• Clark, C. L., Jacobs, M. R., Appelbaum, P. C. (1999). Activities of Clinafloxacin, Alone and in Combination with Other Compounds, against 45 Gram-Positive and -Negative Organisms for Which Clinafloxacin MICs Are High. Antimicrob. Agents Chemother. 43: 2295-2298 [Abstract] [Full Text]  
• Ednie, L. M., Jacobs, M. R., Appelbaum, P. C. (1998). Comparative Activities of Clinafloxacin against Gram-Positive and -Negative Bacteria. Antimicrob. Agents Chemother. 42: 1269-1273 [Abstract] [Full Text]  
• Fuchs, P. C., Barry, A. L., Brown, S. D. (1998). In Vitro Activities of Clinafloxacin against Contemporary Clinical Bacterial Isolates from 10 North American Centers. Antimicrob. Agents Chemother. 42: 1274-1277 [Abstract] [Full Text]  
• Friedland, I. R., McCracken, G. H. (1994). Management of Infections Caused by Antibiotic-Resistant Streptococcus Pneumoniae. NEJM 331: 377-382 [Full Text]