This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukasawa, M
Right arrow Articles by Sunagawa, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukasawa, M
Right arrow Articles by Sunagawa, M

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1992 July; 36(7): 1577-1579

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I.

M Fukasawa, Y Sumita, E T Harabe, T Tanio, H Nouda, T Kohzuki, T Okuda, H Matsumura and M Sunagawa

Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.

ABSTRACT

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1 beta-methyl substituent on carbapenems, i.e., meropenem and 1 beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

Antimicrob Agents Chemother. 1992 July; 36(7): 1577-1579




This article has been cited by other articles:

  • Morinaga, Y., Yanagihara, K., Nakamura, S., Yamamoto, K., Izumikawa, K., Seki, M., Kakeya, H., Yamamoto, Y., Yamada, Y., Kohno, S., Kamihira, S. (2008). In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model. J Antimicrob Chemother 62: 1326-1331 [Abstract] [Full Text]  
  • Shibayama, T., Matsushita, Y., Kawai, K., Hirota, T., Ikeda, T., Kuwahara, S. (2007). Pharmacokinetics and Disposition of CS-023 (RO4908463), a Novel Parenteral Carbapenem, in Animals. Antimicrob. Agents Chemother. 51: 257-263 [Abstract] [Full Text]  
  • Padilla, E., Alonso, D., Domenech-Sanchez, A., Gomez, C., Perez, J. L., Alberti, S., Borrell, N. (2006). Effect of Porins and Plasmid-Mediated AmpC {beta}-Lactamases on the Efficacy of {beta}-Lactams in Rat Pneumonia Caused by Klebsiella pneumoniae.. Antimicrob. Agents Chemother. 50: 2258-2260 [Abstract] [Full Text]  
  • Ueda, Y., Kanazawa, K., Eguchi, K., Takemoto, K., Eriguchi, Y., Sunagawa, M. (2005). In Vitro and In Vivo Antibacterial Activities of SM-216601, a New Broad-Spectrum Parenteral Carbapenem. Antimicrob. Agents Chemother. 49: 4185-4196 [Abstract] [Full Text]  
  • Robatel, C., Decosterd, L. A., Biollaz, J., Eckert, P., Schaller, M. D., Buclin, T. (2003). Pharmacokinetics and Dosage Adaptation of Meropenem during Continuous Venovenous Hemodiafiltration in Critically Ill Patients. J Clin Pharmacol 43: 1329-1340 [Abstract] [Full Text]  
  • Ueda, Y., Sunagawa, M. (2003). In Vitro and In Vivo Activities of Novel 2-(Thiazol-2-ylthio)-1{beta}-Methylcarbapenems with Potent Activities against Multiresistant Gram-Positive Bacteria. Antimicrob. Agents Chemother. 47: 2471-2480 [Abstract] [Full Text]  
  • Park, S. W., We, J. S., Kim, G. W., Choi, S. H., Park, H. S. (2002). Stability of New Carbapenem DA-1131 to Renal Dipeptidase (Dehydropeptidase I). Antimicrob. Agents Chemother. 46: 575-577 [Abstract] [Full Text]  
  • Yang, Y., Testa, R. T., Bhachech, N., Rasmussen, B. A., Bush, K. (1999). Biochemical Characterization of Novel Tetrahydrofuranyl 1beta -Methylcarbapenems: Stability to Hydrolysis by Renal Dehydropeptidases and Bacterial beta -Lactamases, Binding to Penicillin Binding Proteins, and Permeability Properties. Antimicrob. Agents Chemother. 43: 2904-2909 [Abstract] [Full Text]  
  • Krueger, W. A., Schroeder, T. H., Hutchison, M., Hoffmann, E., Dieterich, H.-J., Heininger, A., Erley, C., Wehrle, A., Unertl, K. (1998). Pharmacokinetics of Meropenem in Critically Ill Patients with Acute Renal Failure Treated by Continuous Hemodiafiltration. Antimicrob. Agents Chemother. 42: 2421-2424 [Abstract] [Full Text]  
  • Yamaguchi, K., Domon, H., Miyazaki, S., Tateda, K., Ohno, A., Ishii, K., Matsumoto, T., Furuya, N. (1998). In Vitro and In Vivo Antibacterial Activities of CS-834, a New Oral Carbapenem. Antimicrob. Agents Chemother. 42: 555-563 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»