This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Similar articles in ASM journals Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Alder, J Articles by Clement, J Search for Related Content PubMed PubMed Citation Articles by Alder, J Articles by Clement, J

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1993 June; 37(6): 1329-1333

Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo.

J Alder, M Mitten, K Jarvis, P Gupta and J Clement

Anti-Infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500.

ABSTRACT

Clarithromycin provided effective therapy against arthritis induced by Borrelia burgdorferi infection in the hamster. In vitro, clarithromycin was at least 1 log more potent than tetracycline against two isolates of B. burgdorferi from human sources, as measured by MICs and 50% inhibitory concentrations. Clarithromycin was effective in preventing the onset of B. burgdorferi-induced arthritis, as determined by several parameters of paw swelling. When administered after the onset of arthritis, clarithromycin therapy reduced the degree of swelling and decreased recovery time. These results suggest that clarithromycin has potential as an effective therapy for Lyme disease.

---

Antimicrob Agents Chemother. 1993 June; 37(6): 1329-1333