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Antimicrob Agents Chemother. 1994 May; 38(5): 1203-1204

Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever.

B J Currie, T Burt and E L Kaplan

Menzies School of Health Research, Darwin, Northern Territory, Australia.

ABSTRACT

Plasma penicillin levels were studied 2, 3, and 4 weeks after intramuscular benzathine penicillin G (BPG) doses of 1,200,000, 1,800,000, and 2,400,000 U. Proportions of patients with penicillin levels above 25 ng/ml at each week increased with increasing BPG dose. Further studies of higher-dose BPG for rheumatic fever prophylaxis are required.

Antimicrob Agents Chemother. 1994 May; 38(5): 1203-1204






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