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Antimicrobial Agents and Chemotherapy, Feb 1995, 564-566, Vol 39, No. 2
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli

JS Chapman, A Bertasso, LM Cummings and NH Georgopapadakou
Roche Research Center, Nutley, New Jersey 07110, USA.

Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23- 9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitrocephin, and the penicillin-binding protein profiles were normal.




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