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Antimicrobial Agents and Chemotherapy, Jun 1995, 1265-1268, Vol 39, No. 6
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Susceptibility of Encephalitozoon cuniculi to several drugs in vitro

FF Franssen, JT Lumeij and F van Knapen
Department of Parasitology and Tropical Veterinary Medicine, University of Utrecht, The Netherlands.

In the light of the increased incidence of human Encephalitozoon infections and the absence of an established treatment protocol, a simple in vitro testing method to compare activities of drugs against Encephalitozoon cuniculi was developed. With this in vitro method, the 50% inhibitory concentrations of fumagillin, thiabendazole, albendazole, oxibendazole, and propamidine isethionate for E. cuniculi in rabbit kidney cells were determined. Itraconazole, toltrazuril, metronidazole, ronidazole, and ganciclovir were ineffective in this testing system.


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