This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kobayashi, K.
Right arrow Articles by Nakamura, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kobayashi, K.
Right arrow Articles by Nakamura, R. M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, Jun 1995, 1369-1371, Vol 39, No. 6
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Protection of mice from Mycobacterium avium infection by recombinant interleukin-12

K Kobayashi, T Kasama, J Yamazaki, M Hosaka, T Katsura, T Mochizuki, K Soejima and RM Nakamura
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.


This article has been cited by other articles:

  • Ruan, S., McKinley, L., Zheng, M., Rudner, X., D'Souza, A., Kolls, J. K., Shellito, J. E. (2008). Interleukin-12 and Host Defense against Murine Pneumocystis Pneumonia. Infect. Immun. 76: 2130-2137 [Abstract] [Full Text]  
  • Fattorini, L., Nisini, R., Fan, Y., Li, Y.-J., Tan, D., Mariotti, S., Teloni, R., Iona, E., Orefici, G. (2002). Exposure of BALB/c mice to low doses of Mycobacterium avium increases resistance to a subsequent high-dose infection. Microbiology 148: 3173-3181 [Abstract] [Full Text]  
  • Wagner, D., Sangari, F. J., Kim, S., Petrofsky, M., Bermudez, L. E. (2002). Mycobacterium avium infection of macrophages results in progressive suppression of interleukin-12 production in vitro and in vivo. J. Leukoc. Biol. 71: 80-88 [Abstract] [Full Text]  
  • Hayashi, T., Rao, S. P., Takabayashi, K., Van Uden, J. H., Kornbluth, R. S., Baird, S. M., Taylor, M. W., Carson, D. A., Catanzaro, A., Raz, E. (2001). Enhancement of Innate Immunity against Mycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase. Infect. Immun. 69: 6156-6164 [Abstract] [Full Text]  
  • Brieland, J. K., Jackson, C., Hurst, S., Loebenberg, D., Muchamuel, T., Debets, R., Kastelein, R., Churakova, T., Abrams, J., Hare, R., O'Garra, A. (2000). Immunomodulatory Role of Endogenous Interleukin-18 in Gamma Interferon-Mediated Resolution of Replicative Legionella pneumophila Lung Infection. Infect. Immun. 68: 6567-6573 [Abstract] [Full Text]  
  • Hayashi, T., Rao, S. P., Meylan, P. R., Kornbluth, R. S., Catanzaro, A. (1999). Role of CD40 Ligand in Mycobacterium avium Infection. Infect. Immun. 67: 3558-3565 [Abstract] [Full Text]  
  • Car, B. D., Eng, V. M., Lipman, J. M., Anderson, T. D. (1999). The Toxicology of Interleukin-12: A Review. Toxicol Pathol 27: 58-63 [Abstract]  
  • Bala, S., Hastings, K. L., Kazempour, K., Inglis, S., Dempsey, W. L. (1998). Inhibition of Tumor Necrosis Factor Alpha Alters Resistance to Mycobacterium avium Complex Infection in Mice. Antimicrob. Agents Chemother. 42: 2336-2341 [Abstract] [Full Text]  
  • Doherty, T. M., Sher, A. (1998). IL-12 Promotes Drug-Induced Clearance of Mycobacterium avium Infection in Mice. J. Immunol. 160: 5428-5435 [Abstract] [Full Text]  
  • Brieland, J. K., Remick, D. G., LeGendre, M. L., Engleberg, N. C., Fantone, J. C. (1998). In Vivo Regulation of Replicative Legionella pneumophila Lung Infection by Endogenous Interleukin-12. Infect. Immun. 66: 65-69 [Abstract] [Full Text]  
  • Hoag, K. A., Lipscomb, M. F., Izzo, A. A., Street, N. E. (1997). IL-12 and IFN-gamma Are Required for Initiating the Protective Th1 Response to Pulmonary Cryptococcosis in Resistant C.B-17 Mice. Am. J. Respir. Cell Mol. Bio. 17: 733-739 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»