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Antimicrobial Agents and Chemotherapy, Jan 1996, 11-13, Vol 40, No. 1
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Excretion of ciprofloxacin into the large bowel of the rabbit

J Ramon, S Dautrey, R Farinoti, C Carbon and E Rubinstein
Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel- Hashomer, Israel.

The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral dose of 27 mg of ciprofloxacin per kg of body weight. The elimination rates of ciprofloxacin were 0.126 +/- 0.084 micrograms.min-1.cm-2 in the cecum and 0.264 +/- 0.126, 0.11 +/- 0.07, and 0.21 +/- 0.141 micrograms.min-1.cm-2 in the proximal colon, distal colon, and sigmoid colon, respectively. The calculated fraction of ciprofloxacin eliminated in the large bowel was 3% of the parenteral dose administered. The elimination pattern of ciprofloxacin in the large bowel may explain the unusual activity of this fluoroquinolone in modifying the colonic flora.


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