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Antimicrobial Agents and Chemotherapy, Dec 1996, 2891-2893, Vol 40, No. 12
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae

CA Widdowson, KP Klugman and D Hanslo
MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, South African Institute for Medical Research, Hillbrow, Johannesburg, South Africa.

Five isolates of Streptococcus pneumoniae resistant to tetracycline but lacking tet(M) were studied. The tetracycline resistance gene, tet(O), was detected for the first time in the pneumococcus. The gene was amplified and sequenced and found to share 99% nucleotide sequence identity and 99, 99, and 98% deduced amino acid sequence identity with the tet(O) resistance genes of Streptococcus mutans, Campylobacter coli, and Campylobacter jejuni, respectively.


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