This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dhillon, J.
Right arrow Articles by Mitchison, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dhillon, J.
Right arrow Articles by Mitchison, D. A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, Mar 1996, 552-555, Vol 40, No. 3
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Preventive chemotherapy of tuberculosis in Cornell model mice with combinations of rifampin, isoniazid, and pyrazinamide

J Dhillon, JM Dickinson, K Sole and DA Mitchison
Department of Bacteriology and Infectious Diseases, Royal Postgraduate Medical School, London, United Kingdom.

The efficacies of rifampin-containing preventive regimens were measured in Cornell model mice in which an initially severe infection with Mycobacterium tuberculosis H37Rv was first treated for 7 weeks with 25 mg of isoniazid and 1,000 mg of pyrazinamide per kg of body weight in the diet and then with one of four test regimens given by daily oral gavage for 6 weeks. These regimens were 15 mg of rifampin per kg alone (R), rifampin plus 25 mg of isoniazid per kg (RH), rifampin plus 150 mg of pyrazinamide per kg (RZ), or rifampin plus isoniazid and pyrazinamide (RHZ). The interval between the rifampin gavage and the gavage with the other drugs ranged from 10 to 45 min, so that interference with rifampin absorption did not occur. Mice were sacrificed at 11 and 20 weeks after the termination of chemotherapy, with each killing being preceded by 3 weeks of high-dose dihydrocortisone treatment. Entire spleens and lungs were cultured. The proportions of mice with positive spleens at either killing time were 74% of 43 mice treated with R, 63% of 41 mice treated with RH, 65% of 43 mice treated with RZ, and 53% of 45 mice treated with RHZ, a just significant (P = 0.04) trend for fewer positive spleens with increasing numbers of drugs in the regimen. However, no trend was found in the corresponding proportions of mice with positive spleens or lungs, which were 81, 63, 65, and 71% for mice treated with R, RH, RZ, and RHZ, respectively. Thus, in the Cornell model, R alone, RH, RZ, and RHZ all had similar efficacies.


This article has been cited by other articles:

  • Almeida, D., Nuermberger, E., Tasneen, R., Rosenthal, I., Tyagi, S., Williams, K., Peloquin, C., Grosset, J. (2009). Paradoxical Effect of Isoniazid on the Activity of Rifampin-Pyrazinamide Combination in a Mouse Model of Tuberculosis. Antimicrob. Agents Chemother. 53: 4178-4184 [Abstract] [Full Text]  
  • Williams, K. N., Brickner, S. J., Stover, C. K., Zhu, T., Ogden, A., Tasneen, R., Tyagi, S., Grosset, J. H., Nuermberger, E. L. (2009). Addition of PNU-100480 to First-Line Drugs Shortens the Time Needed to Cure Murine Tuberculosis. Am. J. Respir. Crit. Care Med. 180: 371-376 [Abstract] [Full Text]  
  • Williams, K. N., Stover, C. K., Zhu, T., Tasneen, R., Tyagi, S., Grosset, J. H., Nuermberger, E. (2009). Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model. Antimicrob. Agents Chemother. 53: 1314-1319 [Abstract] [Full Text]  
  • Tasneen, R., Tyagi, S., Williams, K., Grosset, J., Nuermberger, E. (2008). Enhanced Bactericidal Activity of Rifampin and/or Pyrazinamide When Combined with PA-824 in a Murine Model of Tuberculosis. Antimicrob. Agents Chemother. 52: 3664-3668 [Abstract] [Full Text]  
  • Ibrahim, M., Andries, K., Lounis, N., Chauffour, A., Truffot-Pernot, C., Jarlier, V., Veziris, N. (2007). Synergistic Activity of R207910 Combined with Pyrazinamide against Murine Tuberculosis. Antimicrob. Agents Chemother. 51: 1011-1015 [Abstract] [Full Text]  
  • Lardizabal, A., Passannante, M., Kojakali, F., Hayden, C., Reichman, L. B. (2006). Enhancement of Treatment Completion for Latent Tuberculosis Infection With 4 Months of Rifampin. Chest 130: 1712-1717 [Abstract] [Full Text]  
  • Nuermberger, E., Rosenthal, I., Tyagi, S., Williams, K. N., Almeida, D., Peloquin, C. A., Bishai, W. R., Grosset, J. H. (2006). Combination Chemotherapy with the Nitroimidazopyran PA-824 and First-Line Drugs in a Murine Model of Tuberculosis.. Antimicrob. Agents Chemother. 50: 2621-2625 [Abstract] [Full Text]  
  • Tyagi, S., Nuermberger, E., Yoshimatsu, T., Williams, K., Rosenthal, I., Lounis, N., Bishai, W., Grosset, J. (2005). Bactericidal Activity of the Nitroimidazopyran PA-824 in a Murine Model of Tuberculosis. Antimicrob. Agents Chemother. 49: 2289-2293 [Abstract] [Full Text]  
  • Nuermberger, E. L., Yoshimatsu, T., Tyagi, S., O'Brien, R. J., Vernon, A. N., Chaisson, R. E., Bishai, W. R., Grosset, J. H. (2004). Moxifloxacin-containing Regimen Greatly Reduces Time to Culture Conversion in Murine Tuberculosis. Am. J. Respir. Crit. Care Med. 169: 421-426 [Abstract] [Full Text]  
  • Qurrat-ul-Ain, , Sharma, S., Khuller, G. K., Garg, S. K. (2003). Alginate-based oral drug delivery system for tuberculosis: pharmacokinetics and therapeutic effects. J Antimicrob Chemother 51: 931-938 [Abstract] [Full Text]  
  • Joint Tuberculosis Committee of the British Thorac, (2000). Control and prevention of tuberculosis in the United Kingdom: Code of Practice 2000. Thorax 55: 887-901 [Abstract] [Full Text]  
  • (2000). Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection . This Official Statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. This is a Joint Statement of the American Thoracic Society (ATS) and the Centers for Disease Control and Prevention (CDC). This Statement was endorsed by the Council of the Infectious Diseases Society of America (IDSA), September 1999, and the sections of this Statement as it relates to infants and children were endorsed by the American Academy of Pediatrics (AAP), August 1999.. Am. J. Respir. Crit. Care Med. 161: S221-247 [Full Text]  
  • Miyazaki, E., Chaisson, R. E., Bishai, W. R. (1999). Analysis of Rifapentine for Preventive Therapy in the Cornell Mouse Model of Latent Tuberculosis. Antimicrob. Agents Chemother. 43: 2126-2130 [Abstract] [Full Text]  
  • Brooks, J. V., Furney, S. K., Orme, I. M. (1999). Metronidazole Therapy in Mice Infected with Tuberculosis. Antimicrob. Agents Chemother. 43: 1285-1288 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»