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Antimicrobial Agents and Chemotherapy, May 1996, 1298-1300, Vol 40, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations

S Merali, K Chin, RW Grady and AB Clarkson Jr
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016, USA.

In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS- associated P.carinii pneumonia.

This article has been cited by other articles:

• Merali, S., Frevert, U., Williams, J. H., Chin, K., Bryan, R., Clarkson, A. B. Jr. (1999). Continuous axenic cultivation of Pneumocystis carinii. Proc. Natl. Acad. Sci. USA 96: 2402-2407 [Abstract] [Full Text]