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Antimicrobial Agents and Chemotherapy, 06 1996, 1335-1337, Vol 40, No. 6
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Rifapentine is active in vitro and in vivo against Toxoplasma gondii

FG Araujo, AA Khan and JS Remington
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301, USA. ml.fga@forsythe.stanford.edu

Rifapentine, a derivative of rifamycin, was examined for its in vitro and in vivo activities against the protozoan parasite Toxoplasma gondii. The drug inhibited the intracellular replication of parasites and was not cytotoxic for the host cells at inhibitory concentrations. Mice infected either intraperitoneally with tachyzoites of the RH strain or orally with tissue cysts of the C56 strain were protected against death by treatment with rifapentine. The degree of protection was similar to that induced by atovaquone and apparently higher than that induced by rifabutin. Rifapentine may be a useful drug for the treatment of toxoplasmosis in immunocompromised individuals.

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