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Antimicrobial Agents and Chemotherapy, Sep 1996, 2209-2211, Vol 40, No. 9
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Once-daily aminoglycoside therapy: potential ototoxicity

C Singer, C Smith and D Krieff
Department of Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.

Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic. Our experience with once-daily gentamicin, 6 mg/kg of body weight led to a 10% (3 of 33 patients) occurrence of documented ototoxicity after prolonged aminoglycoside exposure.

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