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Antimicrobial Agents and Chemotherapy, Jan 1997, 218-221, Vol 41, No. 1
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic

SJ Andersen, S Quan, B Gowan and ER Dabbs
Genetics Department, University of the Witwatersrand, Johannesburg, South Africa.

A DNA clone from Rhodococcus equi conferring low-level rifampin resistance through the ability to inactivate this antibiotic via its decomposition was identified. The iri (inactivation of rifampin) gene consisted of an open reading frame of 1,437 bp encoding a 479-amino- acid sequence strongly resembling those of monooxygenases acting upon phenolic compounds or involved in polyketide antibiotic synthesis. When expressed in Escherichia coli, the gene conferred resistance to a > 50- micrograms/ml concentration of the drug.


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